Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Blood
Patent
1994-11-16
1997-06-10
Budens, Robert D.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Blood
424 9371, 424577, 424 852, 530413, C12N 1585, A61K 3514, A01N 6300
Patent
active
056373236
ABSTRACT:
This invention provides a method of isolating an increased number of hematopoietic stem cells from a subject comprising a) administering interleukin-7 to the subject in an amount that mobilizes the hematopoietic stem cells to the peripheral blood; and, b) isolating a population of leukocytes enriched for hematopoietic stem cells from the peripheral blood. Also provided is a method of transplanting an increased number of hematopoietic stem cells from a donor to a recipient to enhance repopulation of the recipient's hematopoietic and immune cells comprising a) administering interleukin-7 to the donor in an amount that mobilizes the hematopoietic stem cells to the peripheral blood; b) isolating a population of leukocytes enriched for hematopoietic stem cells from the donor's peripheral blood; and, c) transplanting the isolated population of leukocytes enriched for hematopoietic stem cells to the recipient, thereby enhancing the repopulation of the recipient's hematopoietic and immune cells. Finally, the invention provides a method of improving engraftment of a bone marrow transplant or a peripheral blood leukocyte transplant from a donor to a recipient comprising administering interleukin-7 to the recipient following transplantation in an amount that enhances engraftment.
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Grzegorzewski Krzysztof
Keller Jonathan
Komschlies-McConville Kristin L.
Ruscetti Francis
Wiltrout Robert H.
Budens Robert D.
Reeves Julie E.
The United States of America as represented by the Department of
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