Method of minimizing cell lysis and toothpaste and mouthwash...

Drug – bio-affecting and body treating compositions – Dentifrices

Reexamination Certificate

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C424S052000, C433S216000

Reexamination Certificate

active

07128898

ABSTRACT:
Oral hygiene preparations, an associated method, and kit for utilizing same is disclosed and wherein the oral hygiene preparations reduce the incidence of caries in patients, including immunocomprimised and chemotherapy treated patients. The method includes contacting the patient's teeth and surrounding oral cavity with a toothpaste and mouthwash composition comprising a therapeutically effective amount of Cetyl Pyridinium Chloride and Dehydroacetic Acid; and exposing the patient's dental appliances and toothbrush periodically to a disinfecting solution comprising a therapeutically effective amount of Cetyl Pyridinium Chloride and Dehydroacetic Acid.

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Bauer C. et al. The Effect of SLS and Sodium Dehydroacetate on the Enzymes of the Gastrointestinal Tract. J Am Pharmaceutical Assoc 45(10675-8, Oct. 1956.
Shiota T. Effect of Fluoride, Iodoacetic Acid, Penicillin, SLS and Dehydroacetic Acid on Certain Oral Bacteria of White Rats Fed a Smooth Surface Caries Diet. J Am Dent Assoc 55(2)205-210, Aug. 1957.
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Meier S. et al.; “An In Vitro Investigation of the Efficacy of CPC for Use in Toothbrush Decontamination”; Journal of Dental Hygiene; vol. 70, No. 4, pp. 161-165, Jul.-Aug. 1996.
Invittox Protocol No. 99 “Red Blood Cell Lysis and Protein Denaturation”, Jun. 1994.
Copy of the International Search Report dated May 25, 2000.

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