Method of measuring the activity of G(alpha)i- or...

Details Method of measuring the activity of G(alpha)i- or... Method of measuring the activity of G(alpha)i- or...

2008-12-16

2010-11-09

Ulm, John D (Department: 1649)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100, C435S007210, C436S501000

Reexamination Certificate

active

07829300

ABSTRACT:
A method of measuring the activation or deactivation of G(alpha)i- or G(alpha)o-coupled receptors, and methods of identifying agonists or antagonists of such receptors.

REFERENCES:
patent: 2002/0051980 (2002-05-01), Witte et al.
patent: WO 00/49416 (2000-08-01), None
Gopalakrishnan S M et al., “A cell-based microarrayed compound screening format for identifying agonists of G-protein-coupled receptors”. Annalytical Biochemistry, Academic Press, San Diego, CA, US Bd. 321, Nr. 2, Oct. 15, 2003, Seiten 192-201, XP004457157, ISSN: 0003-2697 das ganze Dokument.
Stables Jenny et al., “A bioluminescent assay for agonist activity at potentially any G-protein-coupled receptor” Analytical Biochemistry, Bd. 252, Nr. 1, 1997, Seiten 115-126, XP002274702, ISSN:003-2697, Zusammenfassung; Abbildungen 3, 5, 8.
Coward Peter et al.: “Chimeric G proteins allow a high-throughput signaling assay of Gi-coupled receptors” Analytical Biochemistry, Bd. 270, Jun. 1, 1999, Seiten 242-248, XP002274703, ISSN: 0003-2697, Zusammenfassung.
International Search Report dated Apr. 16, 2004 (8 pages).
Okajima et al. Synergism in cytosolioc Ca30mobilization between bradykinin and agonists for pertussis toxin-sensitive G-protein-coupled receptors in NG 108-15 cells. Apr. 1992, FEBS Letters 301(2):223-226.
Selbie et al. G protein-coupled-receptor cross-talk: the fine-tuning of multiple receptor-signaling pathways. Mar. 1998, TIPS 19:87-93.

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