Method of measuring chemical concentration iontophoretically usi

Details Method of measuring chemical concentration iontophoretically usi Method of measuring chemical concentration iontophoretically usi

1997-10-29

1998-10-27

Bahr, Jennifer

Surgery

Diagnostic testing

Measuring or detecting nonradioactive constituent of body...

600347, 604 20, 604304, A61N 130

Patent

active

058271830

ABSTRACT:
A method for measuring the concentration of a chemical present in a blood stream of a mammalian subject is disclosed. The method involves contacting the subject's skin with a sensor assembly comprised of an ionically conducting material which contacts the skin, a working electrode which is in contact with the ionically conducting material which electrode has a catalytic surface and a mask having an opening therein. The mask is positioned between the skin and the working electrode. When the electrode is activated, chemical is transported through the skin and the ionically conductive material. The mask is positioned so that it blocks the flow into the catalytic surface except for flow which is substantially axially to the catalytic surface. Electrical signal generated at the working electrode is monitored over a period of time and correlated with a concentration of chemical present in the blood stream of the mammalian subject. The mask reduces or eliminates chemical signal which can radially transport toward the working electrode thereby reducing or eliminating edge effects making it possible to obtain a more accurate measurement.

REFERENCES:
patent: 4477971 (1984-10-01), Jacobsen et al.
patent: 4595011 (1986-06-01), Phillips
patent: 4633879 (1987-01-01), Ong
patent: 4657748 (1987-04-01), Lattin et al.
patent: 4702732 (1987-10-01), Powers et al.
patent: 4722726 (1988-02-01), Sunderson et al.
patent: 4722761 (1988-02-01), Cartmell et al.
patent: 4731049 (1988-03-01), Parsi
patent: 4732155 (1988-03-01), Zetter et al.
patent: 4752285 (1988-06-01), Petelenz et al.
patent: 4968297 (1990-11-01), Jacobsen et al.
patent: 5003987 (1991-04-01), Grinwald
patent: 5036861 (1991-08-01), Sembrowich et al.
patent: 5037380 (1991-08-01), Jacobsen et al.
patent: 5057072 (1991-10-01), Phipps
patent: 5076273 (1991-12-01), Schoendorfer et al.
patent: 5139023 (1992-08-01), Stanley et al.
patent: 5140985 (1992-08-01), Schroeder et al.
patent: 5250022 (1993-10-01), Chien et al.
patent: 5279563 (1994-01-01), Glikfeld et al.
patent: 5362307 (1994-11-01), Guy et al.
Glikfeld, Peretz, et al., "Noninvasive Sampling of Biological Fluids by Iontophoresis", Pharm Res. (US), 1989, vol. 6, No. 11, pp. 988-990.
Meyerhoff et al., "On Line Continuous Monitoring of Subcutaneous Tissue Glucose in Men by Combining Portable Glucosensor with Microdialysis", Diabetologia (Germany), 1992, vol. 35, No. 11, pp. 1087-1092.

Affiliated with

Also associated with

Rating

Method of measuring chemical concentration iontophoretically usi does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of measuring chemical concentration iontophoretically usi, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of measuring chemical concentration iontophoretically usi will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1609895