Method of measuring binding site on plasma protein of plasma...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Reexamination Certificate

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10532819

ABSTRACT:
The present invention relates to a method for readily determining the binding site on plasma protein and binding displacement effect of a drug having binding affinity to plasma protein, and application of the method to clinical diagnosis. That is to say, the present invention provides a method for determining the binding site with plasma protein of a first drug, comprising reacting the first drug for which the binding site with plasma protein is to be determined, with a second drug of which the binding site with plasma protein is known and plasma protein, and determining the change in the ratio of the first drug freed due to the binding of the plasma protein with the second drug.

REFERENCES:
patent: WO 00/78352 (2000-12-01), None
Pritchard et al., Plasma Protein Binding of Bepridil, J Clin Pharmacol, 1985, 25, pp. 347-353.
Kawai, et al. “Competitive displacement of 99mTc-MAG3 serum protein binding in in-vitro and in-vivo”,J. Labelled Cpd. Radiopharm. vol. 42, Suppul. 1(1999).

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