Method of mass spectrometry

Radiant energy – Ionic separation or analysis – Cyclically varying ion selecting field means

Reexamination Certificate

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Details

C250S290000, C250S283000, C250S282000, C250S281000

Reexamination Certificate

active

07635841

ABSTRACT:
A method of mass spectrometry is disclosed wherein ions are trapped for a period of time T within an AC or RF ion guide maintained at a pressure P wherein the product P×T is at least 1 mbar-ms. The effect of trapping the ions according to a preferred embodiment is that singly charged ions which may, for example, comprise unwanted background ions are substantially lost from the trap whereas multiply charged analyte ions are maintained within the ion trap and can then be released for subsequent mass analysis.

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patent: 2 381 948 (2003-05-01), None
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patent: WO02/097412 (2002-12-01), None
Scalf et al., “Controlling Charge States of Large Ions”, Jan. 8, 1999, vol. 283, pp. 194-197.
Tolmachev, et al.; Radial stratification of ions as a function of mass to charge ratio in collisional cooling radio frequency multipoles used as ion guides or ion traps; Rapid Communications in Mass Spectrometry, pp. 1907-1913 (2000).
Guevremont, et al.; Ion trapping at atmospheric pressure (760 Tor) and room temperature with a high-field asymmetric waveform ion mobility spectrometer; International Journal of Mass Spectrometry 193 (1999) 45-56.

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