Method of manufacturing unilamellar lipid vesicles

Details Method of manufacturing unilamellar lipid vesicles Method of manufacturing unilamellar lipid vesicles

1987-07-28

1989-08-01

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

436829, A61K 962

Patent

active

048532282

ABSTRACT:
Disclosed is a new type of unilamellar lipid vesicle made from polyoxyethylene acyl ethers or sorbitan alkyl esters. These unilamellar vesicles are made with easily obtained, relatively inexpensive materials and the vesicles are more stable then conventional unilamellar lipid vesicles. A delivery system for drugs or other molecules is also disclosed.

REFERENCES:
patent: 3957971 (1976-05-01), Oleniacz
patent: 4133874 (1979-01-01), Miller et al.
patent: 4182330 (1980-01-01), Michaels
patent: 4217344 (1980-08-01), Vanlerberghe et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4241046 (1980-12-01), Papahadjopoulous et al.
patent: 4247411 (1981-01-01), Vanlerberghe et al.
patent: 4348329 (1982-09-01), Chapman
patent: 4356167 (1982-10-01), Kelly
patent: 4377567 (1983-03-01), Geho
patent: 4485054 (1984-11-01), Mezei et al.
patent: 4536324 (1985-08-01), Fujiwara et al.
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4551288 (1985-11-01), Kelly
patent: 4564599 (1986-01-01), Janoff et al.
patent: 4608211 (1986-08-01), Handjani et al.
patent: 4610868 (1986-09-01), Fountain et al.
patent: 4619913 (1986-10-01), Luck et al.
patent: 4692433 (1987-09-01), Hostetler et al.
patent: 4695554 (1987-09-01), O'Connell et al.
patent: 4744989 (1988-05-01), Payne et al.
patent: 4772471 (1988-09-01), Vanlerberghe et al.
McCutcheon's Emulsifiers & Detergents, MC Publishing Co., 1982, pp. 246 and 77.
Bangham et al. (1965), J. Mol. Biol., 13238-252.
Gregoriadis (1976), New Eng. J. Med. (1976), 295:704-711.
Szoka, Francis and Papahadjopoulos, Demetrios, Procedure for Preparation of Liposomes with Large Internal Aqueous Space and High Capture by Reverse-Phase Evaporation, Proc. Natl. Acad. Sci U.S.A. (1978), 75:4194-4198.
Puisieux and Poly, "Problemes technologiques poses par l'utilisation des liposomes comme vecteurs de substances medicamenteuses, Encapsulation, sterilisation, conservation," in Les Liposomes, Puiseux and Delattre, Eds., Techniques et Documentation La Voisier, Paris (1980), pp. 73-113.
Dousset and Douste-Blazy, "Methodes de preparation des liposomes," in Les Liposomes, Puisieux and Delattre, Eds., Techniques et Documentation La Voisier, Paris (1980), pp. 41-70.
Handjani-Vila, Ribier, and Vanlerberghe, "Les noisomes," in Les Liposomes, Puisieux and Delattre, Eds., Techniques et Documentation La Voisier, Paris (1980), pp. 297-313.
Philippot et al., A Very Mild Method Allowing the Encapsulation of Very High Amounts of Macromolecules into Very Large (1000 nm) Unilamellar Liposomes, Biochem. Biophys. Acta (1983), 734:137-143.
Ribier and Hanjani-Vila, Bilayer Fluidity of Non-Ionic Vesicles, an Investigation by Differential Polarized Phase Fluorometry, Colloids and Surfaces (1984), 10:155-156.
Philippot et al., Extemporaneous Preparation of Large Unilamellar Liposomes, Biochem. Biophys. Acta (1985), 821:79-84.
Baillie et al., The Preparation and Properties of Niosomes-Non-Ionic Surfactant Vesicles, J. Pharm. Pharmacol. (1985), 37:863-868.
Baillie et al., Non-Ionic Surfactant Vesicles, Niosomes, as a Delivery System for the Anti-Leishmanial Drug, Sodium Stibogluconate, J. Pharm. Pharmacol. (1986), 38:502-505.
"Liposomes," Edited by Marc J. Ostro, The Liposome Co., Princeton, N.J., Marcel Dekker, Inc., New York, pp. 246-249 (1983).

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