Method of manufacturing an antihypertensive, diuretic and antihy

Details Method of manufacturing an antihypertensive, diuretic and antihy Method of manufacturing an antihypertensive, diuretic and antihy

1987-03-27

1988-12-27

Schofer, Joseph L.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424464, 424 78, 5142235, A61K 3174

Patent

active

047939990

ABSTRACT:
A novel method of manufacturing a novel effective antihypertensive, diuretic and antihypokalemic pharmaceutical composition in which a triamterene active pteridine, a hydrochlorothiazide active benzothiadiazide, and a filler are thoroughly mixed with a polyethylene glycol, applying heat to the melting point thereof when the mixture instantaneously fuses to form granules, while cooled, then the granules are formulated into effective dosage units.

REFERENCES:
patent: 3163576 (1964-12-01), Havemeyer
patent: 4255413 (1981-03-01), Rattle et al.
patent: 4425345 (1984-01-01), Horlington et al.
patent: 4444769 (1984-04-01), Blume et al.
A. V. Deshpande and D. K. Agarwal, "Increasing the Dissolution Rate of Some Benzothiadiazine Derivatives by Solid & Liquid Dispersion Techniques", 8(6) 1982, Drug Development & Industrial Pharmacy, pp. 883-897.
J. K. Pandit & B. K. Khakurel, "In Vitro & In Vivo Evaluation of Some Fast Release Dosage Forms of Hydrochlorthiazide", Oct. 10, 1984, Drug Development & Industrial Pharmacy, pp. 1709-1724.
M. A. Kaslem et al., "On the Dissolution of Hydrochlorthiazide Powders and Solid Dispersions", 44, No. 11, 1982, Pharm. Ind., pp. 1186-1189.

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