Method of manufacturing a vascular graft impregnated with polysa

Surgery – Blood vessel or graft preparation

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623 1, A61F 204, A61F 206

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active

054156190

ABSTRACT:
A vascular graft fabricated of a polyester fiber, the surface of which is impregnated with biodegradable blood-compatible materials, characterized in that the surface of the said vascular graft comprises carboxylate groups and is impregnated with polysaccharides or their derivatives. The vascular graft is manufactured by treating the hydrophobic surface of a vascular graft fabricated of a polyester fiber to render it more hydrophilic and then impregnating the vascular graft with above polysaccharides or their derivatives by chelate bond with metal ions or physical adsorption in order to increase the adhesion properties and adding glycerin to the impregnated polysaccharides or their derivatives in order to increase the softness so that the impregnated substances may turn into the state of gel by blood at the time of use.

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Guidoin, R. et al., Albumin Coating of a Knitted Polyester Arterial Prosthesis An Alternative to Preclotting, The annals of Thoracic Surgery, vol. 37, No. 6, (Jun., 1984).
Urry, D. W. et al., Irradiation crosslinking of the polytetrapeptide of elastin and compounding to dacron to produce a potential prosthetic material with elasticity and strength, Journal of Biomedical Materials Research, vol. 16, pp. 11-16, (1982).

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