Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification
Reexamination Certificate
2007-06-19
2007-06-19
Bunner, Bridget (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Separation or purification
C435S070100, C435S405000, C530S300000, C530S350000
Reexamination Certificate
active
10888962
ABSTRACT:
The present invention provides compositions and methods for selectively inhibiting the proliferation of stellate cells, which are important for the development of liver fibrosis upon liver injury. The invention describes conditioned media from immortalized hepatocytes as containing a death factor that induces apoptosis of activated liver stellate cells. This pro-apoptotic activity is shown to be associated with an 80 kDa protein, which is associated with a fetuin peptide sequence and an albumin peptide sequence.
REFERENCES:
patent: 5869243 (1999-02-01), Jauregui et al.
patent: 5994298 (1999-11-01), Tsai et al.
patent: 6258779 (2001-07-01), Tsai et al.
patent: 2001/0049356 (2001-12-01), Tsai
patent: 2003/0027767 (2003-02-01), Tsai
patent: 2003/0087809 (2003-05-01), Tsai
Basu et al. Stellate cell apoptosis by a soluble mediator from immortalized human hepatocytes. Apoptosis 11: 1391-1400, 2006.
Schippers et al. Immortalized human hepatocytes as a tool for the study of hepatocytic (de-)differentiation. Cell Biol Toxicol 13: 375-386, 1997.
Basu et al., “Hepatitis C Virus Core Protein Is Necessary for the Maintenance of Immortalized Human Hepatocytes,” Virology 298:53-62 (2002).
Basu et al., “Primary Human hepatocytes immortalized by . . . ,” 22nd Annual Meeting, American Society For Virology, Jul. 12-16, 2003, Advise, USA.
Buck et al., “C/EBPbeta Phosphorylation by RSK Creates a Functional XEXD Caspase . . . ,” Molecular Cell 8:807-816 (Oct. 2001).
Yu and Tsai., “Fetal fetuin selectively induces apoptosis . . . ,” Cancer Letters 166:173-184, May 26, 2001 (abstract).
Dziegielewska et al., “The Complete cDNA and Amino Acid Sequence of Bovine Fetuin,” J. Biol. Chem. 265:4354-4357 (Mar. 15, 1990).
Forestier et al., “Application of mRNA differential display to liver cirrhosis . . . ,” Biochem. Biophys. Res. Commun. 225:377-383, Aug. 14, 1996 (abstract).
“Hepatic Fibrosis— Role of Hepatic Stellate Cell Activation part 5 of 6,” HBV Research Archives, 3 pages, Jul. 25, 2002.
ISSA et al., “Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by . . . ,” Gut 48:548-557, 2001.
ISSA et al., “Mutation in collagen-1 that confers resistance to the action of collegenase results in . . . ,” The FASEB Journal 17:47-49, Jan. 2003.
Jahnen-Dechent et al., “Posttranslational processing of human alpha 2-HS glycoprotein . . . ,” Eur. J. Biochem. 226:59-69, Nov. 15, 1994 (abstract).
Ohnishi et al., “Effects of Cytokines and Growth Factors on Phosphorylated Fetuin Biosynthesis . . . ,” Biochem. Biophys. Res. Comm. 200:598-605, Apr. 15, 1994 (abstract).
Ohnishi et al., “Effect of Phosphorylated Rat Fetuin on the Growth of Hepatocytes in Primary Culture . . .,” Eur. J. Biochem. 243:753-761, Feb. 1, 1997 (abstract).
Ray et al., “Hepatitis C Virus Core Protein Promotes Immortalization of Primary Human Hepatocytes,” Virology 271:197-204, 2000.
Yao et al., “Effects of Yigan Decoction on proliferation and apoptosis of hepatic stellate cells,” World J. Gastroenterol. 8:511-514, Jun. 15, 2002.
Zhang et al., “Salvia miltiorrhiza monomer IH764-3 induces hepatic stellate cell apoptosis via caspase-3 activation,” World J. Gastroenterol. 8:515-519. Jun. 15, 2002.
Basu Arnab
Chang Yie-Hwa
Ray Ranjit
Ray Ratna
Bunner Bridget
Saint Louis University
Zahner Joseph E.
LandOfFree
Method of manufacturing a stellate cell death factor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of manufacturing a stellate cell death factor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of manufacturing a stellate cell death factor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3828979