Method of making vitamin K1

Details Method of making vitamin K1 Method of making vitamin K1

1996-12-12

1998-04-28

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclohexadiene having atoms double bonded directly at the 1-...

C07C 5014

Patent

active

057446245

ABSTRACT:
A process for the preparation of vitamin K.sub.1 by the oxidation of an alkali metal salt of dihydrovitamin K.sub.1 with hydrogen peroxide in the presence of an iron (III) salt at a pH of 13.7 to 14.3. The dihydrovitamin K.sub.1 alkali metal salt is produced by the saponification of a dihydrovitamin K.sub.1 diester with sodium hydroxide or potassium hydroxide. Conveniently, the oxidation process follows the saponification of dihydrovitamin K.sub.1 without isolation of the product of the saponification reaction.

REFERENCES:
patent: 1984511 (1934-12-01), Anderson et al.
patent: 2376984 (1945-05-01), Tishler
patent: 3076004 (1963-01-01), Hirschmann
patent: 3948958 (1976-04-01), Rapoport et al.
patent: 4906411 (1990-03-01), Shinnaka et al.
patent: 5075463 (1991-12-01), Kuo et al.
Fieser, L.F., and Cason, J., J.A.C.S., 61:2559-2561 (1939).
Fieser, L.F., and Cason, J., J.A.C.S., 61:3467 & 3471 (1939).
Fieser, L.F., and Cason, J., J.A.C.S., 62:432-436 (1940).
Fieser, L.F., J. Biol. Chem., 133:391-396 (1940).
Houben-Weyl, Methoden der organischen Chemie, vol. VII/3a:27-52 (1977).
Isler, O., and Doebel, K., Helv. Chim. Acta, 37:225 and 230 (1954).
Jackman, L.M., et al., Helv. Chim. Acta, 48:1332&1346 (1965).
Jacob III, P., et al., J. Org. Chem., 41:3627-3629 (1976).
Karrer, P., et al., Helv. Chim. Acta, 27:317-319 (1944).
Mayer, H., et al., Helv. Chim. Acta, 47:221 & 226 (1964).
Morita, E., et al., Chemical Abstracts, 80(9):Abstract No. 48207 (1974).
Ruttimann, A., CHIMIA, 40(9):290-306 (1986).
Schmid, R., et al., Helv. Chim. Acta, 73:1276-1299 (1990).
Woods, et al., Can. J. Chem., 35:941-943 (1957).

Affiliated with

Also associated with

Rating

Method of making vitamin K1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of making vitamin K1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of making vitamin K1 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1533118