Method of making vascular prosthesis by perfusion

Details Method of making vascular prosthesis by perfusion Method of making vascular prosthesis by perfusion

1987-01-27

1990-03-27

Apley, Richard J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Arterial prosthesis

Stent structure

623 11, 623 66, 623901, 8 9411, A61F 206

Patent

active

049117130

ABSTRACT:
A method of making an impermeable vascular prosthesis is disclosed which comprises the steps of treating a porous textile conduit with a first solution of cross-linking agent; perfusing the conduit with a second solution of cross-linking agent and protein; and drying the perfused conduit to allow gelation in a second solution to form an impermeable vascular prosthesis. Perfusion of the lumen of the prosthesis is performed with sufficient pressure to ensure that all interstices of the porous textile conduit are completely filled. A gelation mixture comprising albumin and glutaraldehyde is preferably utilized for perfusion of the prosthesis. Methods for preserving these grafts indefinitely by treatment with glycerol and other alkyl alcohols are also disclosed.

REFERENCES:
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patent: 3438374 (1969-04-01), Falb et al.
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patent: 4358470 (1982-11-01), Rasmussen
patent: 4372743 (1983-02-01), Lane
patent: 4664658 (1987-05-01), Sawada et al.
The American Heritage Dictionary, Second College Edition, 1982, p. 922.

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