Multicellular living organisms and unmodified parts thereof and – Method of making a transgenic nonhuman animal – Via microinjection of dna into an embryo – egg cell – or...
Patent
1992-07-30
1999-08-17
Crouch, Deborah
Multicellular living organisms and unmodified parts thereof and
Method of making a transgenic nonhuman animal
Via microinjection of dna into an embryo, egg cell, or...
800 3, 800 21, 800 8, A61K 4800, C12N 1509
Patent
active
059395982
ABSTRACT:
The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci. The hosts are produced by repetitive transformations of embryonic stem cells by homologous recombination, preferably in conjunction with breeding. Different strategies are employed for recombination of the human loci randomly or at analogous host loci.
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Jakobovits Aya
Kucherlapati Raju
Abgenix, Inc.
Crouch Deborah
Gunnison, Esq. Jane T.
Haley, Jr. Esq. James F.
Hauda Karen M.
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