Method of making radioiodinated pyrimidine nucleoside or nucleot

Details Method of making radioiodinated pyrimidine nucleoside or nucleot Method of making radioiodinated pyrimidine nucleoside or nucleot

1988-01-29

1989-07-25

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 23, C07H 19067, C07H 19073, C07H 1910

Patent

active

048515205

ABSTRACT:
The method of making radioiodinated pyrimidine nucleoside or nucleotide which comprises contacting a water-insoluble halomercuri pyrimidine nucleoside or nucleotide with an aqueous medium containing a dissolved radioactive iodide ion and an oxidizing agent, the molar amounts of said nucleoside or nucleotide and said oxidizing agent being in excess of the molar amount of said iodide, whereby water-soluble radioactive iodinated pyrimidine nucleoside or nucleotide is formed in solution, and separating residual water-insoluble halomercuri pyrimidine nucleoside or nucleotide from said solution.

REFERENCES:
Keough et al., J. Labelled Compd. Radiopharm., vol. 14, pp. 83-90 (1978).
Bakker et al., Int. J. Appl. Radiat. Isot., vol. 32, pp. 176-178 (1981).
Bergstrom et al., J. Carbohyr., Nucleosides, Nucleotides, vol. 4, pp. 257-269 (1977).

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