Method of making pteridine compounds

Details Method of making pteridine compounds Method of making pteridine compounds

1975-03-31

1978-03-14

Coughlan, Jr., Paul M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D47508

Patent

active

040790568

ABSTRACT:
A method for the preparation of pteridine compounds such as methotrexate is disclosed. 2,4-diamino-6-pteridine-methanol.multidot.HBr is reacted with triphenylphosphine dibromide or phosphorus tribromide to form 6-(bromomethyl)-2,4-diamino-pteridine hydrobromide and the bromine atom in the molecule is then replaced with the functional group, N-[4-(methylamino)-benzoyl]-L-glutamic acid in the case of methotrexate and N-(4-aminobenzoyl)-L-glutamic acid in the case of aminopterin.

REFERENCES:
patent: 3509150 (1970-04-01), Sisenwine
Kittila, "Dimethylformamide Chemical Uses", (1967), pp. 81-85.

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