Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1994-02-07
1995-12-12
Naff, David M.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 95, 435 99, 435101, 435135, 536115, 536116, 536119, 536120, 536122, 536124, 536126, C12P 1900, C08F 200, C08F 1804, C07H 1300
Patent
active
054749158
ABSTRACT:
A poly(sugar acrylate) is prepared by reacting vinyl acrylate with a sugar in the presence of hydrolytic enzymes to prepare an acryloyl ester of the sugar. The acryloyl ester of the sugar is then polymerized to form the poly(sugar acrylate). Useful hydrolytic enzymes include alkaline protease, aminoacylase, fungal amylase, bacterial protease, lipase from Pseudomonas cepacia and subtilisin. Useful sugars include .alpha.- or .beta.-alkyl- or .alpha.- or .beta.-halo-glycosides, sucrose, fructose, mannose, trehalose, raffinose, lactose and maltose. A free radical initiator can be used in the polymerization. A copolymer can be formed by mixing the sugar ester with a monomer such as 2-hydroxyethyl methacrylate before polymerizing. During formation of the copolymer, a cross-linking agent such as ethylene glycol dimethacrylate may be present. The poly(sugar acrylates) form hydrogels which are useful in absorbent materials such as diaper liners, packaging materials and drug delivery polymers.
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Dordick Jonathan S.
Linhardt Robert J.
Martin Brett D.
Naff David M.
Prats Francisco C.
University of Iowa Research Foundation
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