Method of making oligonucleotides and oligonucleotide analogs us

Details Method of making oligonucleotides and oligonucleotide analogs us Method of making oligonucleotides and oligonucleotide analogs us

1995-06-05

1997-07-08

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 251, 536 252, 536 253, 536 231, C07H 2102, C07H 2104

Patent

active

056462670

ABSTRACT:
Methods and compounds are provided for solid phase synthesis of oligonucleotides and related polymers by condensing protected monomer-O-[1,3,2-dichalcogen-substituted-phospholane] synthons in the presence of a catalytic base. Compounds of the invention include 2-N-substituted-1,3,2-dichalcogen-substituted-phospholane precursors of the above synthons, the protected monomer-O-[1,3,2-dichalcogen-substituted-phospholane] synthons, and P-chiral oligonucleotides and related P-chiral polymers.

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