Method of making oil filled paucilamellar lipid vesicles

Details Method of making oil filled paucilamellar lipid vesicles Method of making oil filled paucilamellar lipid vesicles

1990-10-16

1992-11-03

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

424450, 4284022, A61K 9127, B01J 1320

Patent

active

051606690

ABSTRACT:
A new "cold-loading" technique for filling the amorphous central cavity of paucilamellar lipid vesicles with a water immiscible material has been developed. Preformed, substantially aqueous filled paucilamellar lipid vesicles are mixed with the water immiscible material to be encapsulated under intermediate mixing conditions, thereby replacing the aqueous solution with the water-immiscible solution. The "cold-loading" technique is particularly useful for encapsulation of volatiles and heat labile materials.

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