Method of making non-pyrogenic lipopolysaccharide or A

Details Method of making non-pyrogenic lipopolysaccharide or A Method of making non-pyrogenic lipopolysaccharide or A

1997-02-19

1999-12-07

Spector, Lorraine

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

435243, 435170, 4242411, 4242531, 4242581, 4242601, 4242611, 4242451, 4242491, 4242401, 4242521, 4242591, A61K 3902

Patent

active

059978813

ABSTRACT:
The present invention provides gram-negative bacterial strains that produce substantially pure non-pyrogenic lipopolysaccharide or lipid A. The present invention also relates to a use of said strains for the preparation of non-pyrogenic DNA and use of the same for introducing endogenous or foreign genes into animal cells or animal tissue. Further, the present invention relates to a use of said strains for the preparation of non-pyrogenic recombinant mammalian, protozoan and viral proteins. Furthermore, the present invention relates to a use of said strains for the preparation of non-pyrogenic bacterial vaccines and vaccine vectors. Yet a further use of the present invention relates to a use of said strains for the preparation of non-pyrogenic bacterial proteins and polysaccharide antigens for use as vaccines.

REFERENCES:
patent: 4595660 (1986-06-01), Ostroff et al.
patent: 5561064 (1996-10-01), Marquet et al.
Karow et al., Journal of Bacteriology 173(2): 741-750, 1991.
Karow et al., Journal of Bacteriology 174: 702-710, 1992
Hansson et al., "Single-Step Recovery of a Secreted Recombinant Protein by Expanded Bed Adsorption," Bio/Technology, vol. 12, Mar. 1994, pp. 285-288.
Schorr et al., "Large Scale Purification of Endotoxin-Free Plasmid DNA for Gene Therapy Research," In: Gene Therapy Meeting Cold Spring Harbor (149). New York: 1994, pp. 21-25 (abstract only).
International Search Report for the corresponding international application .

Affiliated with

Also associated with

Rating

Method of making non-pyrogenic lipopolysaccharide or A does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of making non-pyrogenic lipopolysaccharide or A, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of making non-pyrogenic lipopolysaccharide or A will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-820704