Method of making nanoparticulate X-ray blood pool contrast agent

Details Method of making nanoparticulate X-ray blood pool contrast agent Method of making nanoparticulate X-ray blood pool contrast agent

1994-05-13

1995-09-05

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

X-ray contrast imaging agent

424489, 424499, 424 94, 514 5, 514718, 514975, A61K 4904, A61K 914

Patent

active

054477107

ABSTRACT:
The present invention is directed to a composition comprised of nanoparticles containing an x-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier adsorbed on the surface thereof and a cloud point modifier associated therewith.
The present invention is also directed to a method for making nanoparticles comprising

REFERENCES:
patent: 4406878 (1983-09-01), DeBoer
patent: 4540602 (1985-09-01), Motoyama et al.
patent: 5141703 (1992-05-01), Wolf et al.
patent: 5145684 (1992-09-01), Liversidge et al.

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