Method of making liposomes with improved stability during drying

Details Method of making liposomes with improved stability during drying Method of making liposomes with improved stability during drying

1995-06-06

1998-10-06

Dees, JoseG.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 43, 436829, A61K 910, A61K 9127, B01J 1302

Patent

active

058173340

ABSTRACT:
A composition and method are provided for the making of cholesterol containing phospholipid liposomes such that when dried and then reconstituted, the liposomes retain their structure and size distribution as well as substantially all of the material that was originally encapsulated, and they behave biologically in a normal fashion. The cryoprotective agents are used in the aqueous medium to hydrate the phospholipid(s) and are a combination of at least one sugar and at least one protein, polypeptide, and/or oligopeptide.

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