Method of making lipid tubules by a cooling process

Plastic and nonmetallic article shaping or treating: processes – Encapsulating normally liquid material – Liquid encapsulation utilizing an emulsion or dispersion to...

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264 43, 424450, 514832, 514885, 522171, A61K 9127, B01J 1318

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049902911

ABSTRACT:
Diacetylinic phosophocholines have distinctly different endothermic and exothermic transition temperatures. Lipid tubules are formed by hydrating a diacetylinic phosphocholine at a temperature above its endothermic transition temperature. The hydrated lipid is then cooled slowly to a formation temperature 1.degree. to 10.degree. C. below the exothermic transition temperature to form tubule structures. The tubules structures can be polymerized to form permanent tubules. The tubules can be used in the same manner as a liposome vesicle or they can be metal coated for a variety of applications.

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Yager et al.: "Formation of Tubules by a Polymerizable Surfactant", Mol. st. Liq. Cryst., 1984, vol. 106, pp. 371-381.
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Singh et al.: "Polymerized Diacetylenic Phosphatidyl Choline Vesicles: Synthesis and Characterization", Polymer Preprints, vol. 26, No. 2, pp. 184-185, (Sep. 1985).
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Singh et al.: "Synthesis and Characterization of Positional Isomers of 1,2-Bishepacosadiynoyl Phosphatidyl Cholines", Abstracts of Sixth Int. Symp. on Surfactants in Solution, New Delhi, India, p. 193 (Aug. 18-22, 1986).
Singh et al.: "Tubule Formation by Heterobifunctional Polymerizable Lipids: Synthesis and Characterization", Polymer Preprints, vol. 27, (Sep. 1986).

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