Method of making imidazole-2-ones and 2-thiones

Details Method of making imidazole-2-ones and 2-thiones Method of making imidazole-2-ones and 2-thiones

2006-08-25

2009-08-25

Shiao, Rei-Tsang (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S335100, C548S347100, C514S392000, C514S396000, C514S401000

Reexamination Certificate

active

07579481

ABSTRACT:
A method of 4-substituted imidazole-2-ones and thiones which comprises reacting a methylene urea or methylene thiourea wherein said methylene is substituted with the 4-subsituent and a cyano or alkycarboxylate group to provide said 4-substituted imidazole 2-one or thione.

REFERENCES:
Alker, et al., Long-Acting dihydropyridine calcium Antagonists. 5. Synthesis and structure-activity relationships for a series of 2-[[N-substituted-heterocyclyl) ethoxy] met hyl]-I,4dihydropyridine calcium antagonists, Journal of Medicinal Chemistry, vol. 33, 1990, pp. 1805-1811.
Alker, et al., Long-Acting dihydropyridine calcium Antagonists. 5. Synthesis and structure-activity relationships for a series of 2-[[N-substituted-heterocyclyl) ethoxy] met hyl]-1,4dihydropyridine calcium antagonists, Journal of Medicinal Chemistry, vol. 33, 1990, pp. 1805-1811, XP0024136262.

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