Method of making free acids from polysaccharide salts

Details Method of making free acids from polysaccharide salts Method of making free acids from polysaccharide salts

1997-01-15

1998-08-04

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536119, 536127, C07H 106, C07H 1302, C07H 100

Patent

active

057895716

ABSTRACT:
A free acid form of a polysaccharide is produced from its alkali-metal salt. In one example, free-form hyaluronic acid is produced by preparing a solution of an alkali-metal salt of hyaluronic acid, dispersing into the solution a strong acid, enclosing the dispersion within a semi-permeable membrane, dialyzing the dispersion in water, and harvesting the product from within the membrane. The strong acid can be hydrochloric acid, sulfuric acid, nitric acid, orthophosphoric acid, or oxalic acid, for example. The semi-permeable membrane has a molecular weight cut-off large enough to pass the strong acid, and preferably much larger. The invention provides a simple and economical way to produce a product which is not commercially available.

REFERENCES:
patent: 4589963 (1986-05-01), Cipriano et al.
patent: 4736024 (1988-04-01), Della Valle et al.
patent: 5268079 (1993-12-01), Gomez et al.
patent: 5532221 (1996-07-01), Huang et al.

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