Method of making calcification-resistant bioprosthetic tissue

Details Method of making calcification-resistant bioprosthetic tissue Method of making calcification-resistant bioprosthetic tissue

1993-10-21

1998-05-05

Griffin, Walter D.

Bleaching and dyeing; fluid treatment and chemical modification

Treatment of hides, skins, feathers and animal tissues

Internal tissues

8 9428, 8 9429, 623 1, 623 2, 623 3, 623 12, 623 66, A61F 202, A61F 224, D01C 300

Patent

active

057467757

ABSTRACT:
A method of treating a collagenous biomaterial, such as porcine aortic valve leaflets or bovine pericardium, by exposing the biomaterial to an alcohol to inhibit in vivo calcification. The biomaterial, preferably glutaraldehyde-pretreated, is subjected to an aqueous solution of 60% to 80% lower aliphatic alcohol, such as ethanol for a period of at least 20 minutes, and preferably, 24 to 72 hours. The biomaterial is rinsed, and then stored in either a glutaraldehyde-free environment or an ethanolic solution of glutaraldehyde. In some embodiments, the treatment solutions include an additional anticalcification agent which may be a soluble salt of a metallic cation, such as Al.sup.+3 or Fe.sup.+3.

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