Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from leguminosae
Reexamination Certificate
2005-05-03
2005-05-03
Coe, Susan D. (Department: 1654)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from leguminosae
C424S776000, C435S213000
Reexamination Certificate
active
06887498
ABSTRACT:
A method for preparing a Bowman-Birk inhibitor (BBI) product from soybeans is provided. The product produced in accordance with the method of the invention and compositions including the product are also provided. BBI product produced in accordance with the invention is a significantly improved inhibiter of malignant cell transformation and methods for its administration to prevent or inhibit progression of cancer are provided.
REFERENCES:
patent: 4793996 (1988-12-01), Kennedy et al.
patent: 5217717 (1993-06-01), Kennedy et al.
patent: 5338547 (1994-08-01), Kennedy et al.
Skoog et al. (Fundamental of Organic Chemistry (1988): Saunders College Publishing, New York, p. 736).*
Baturay et al., “Pyrene Acts as a Cocarcinogen with the Carcinogens Benzo [A] Pyrene, β-Propiolactone and Radiation in the Induction of Malignant Transformation in Cultured Mouse Fibroblasts; Soybean Extract Containing the Bowman-Birk Inhibitor Acts as an Anticarcinogen”, 1986Cell Biology and Toxicology2:21-32.
Birk et al., “Isolation of Tribolium-proteolytic-enzyme-inhibitor from soybeans”, 1962Bull. Res. Council IsraelSec. A 11:48.
Birk et al., “Separation of a Tribolium-protease inhibitor from soybeans on a calcium phosphate column”, 1963Biochim. Biophys. Acta, 67:326-328.
Hwang et al., “Purification, Partial Characterization, and Immunological Relationships of Multiple Low Molecular Weight Protease Inhibitors of Soybean”, 1977Biochim. Biophys. Acta495:369-382.
Kakade et al., “Determination of Trypsin Inhibitor Activity of Soy Products:A Collaborative Analysis of an Improved Procedure”, 1974 Cereal Chemistry, 51: 376-382.
Kassell B., Trypsin and Chymotrypsin Inhibitors from Soybeans, 1970Methods in Enzymology19: 860-861.
Kennedy et al., “Anticarcinogenic Actions of Protease Inhibitors”, inAnticarcinogenesis and Radiation Protection, edited by Cerutti et al., Plenum Pub. Co., 1987 pp. 285-295.
Messadi et al., “Inhibition of Oral Carcinogenesis by a Protease Inhibitor”, 1986JNCI76:447-452.
Morris A., “Factors Influencing Experimental Carcinogenesis in the Hamster Cheek Pouch”,J. Dent. Res. 1961 40:3-15.
Salley J., “Experimental Carcinogenesis in the Cheek Pouch of the Syrian Hamster”, 1954J. Dent. Res., 33:253-262.
St. Clair et al., “Suppression of dimethylhydrazine-induced carcinogenesis in mice by dietary addition of the Bowman-Birk Protease Inhibitor”, 1990Cancer Res. 50:580-586.
Weed et al., . “Protection against dimethylhydrazine-induced adenomatous tumors of the mouse colon by the dietary addition of an extract of soybeans containing Bowman-Birk protease inhibitor”, 1985Carcinogenesis6:1239-1241.
Yavelow et al., “Nanomolar concentrations of Bowman-Birk soybean protease inhibitor suppress x-ray-induced transformation in vitro”, 1985Proc. Natl. Acad. Sci. USA 82:5395-5399.
Yavelow et al., “Bowman-Birk Soybean Protease Inhibitor as an Anticarcinogen”, 1983Cancer Res. 43:2454-2459.
Konwinski Arthur H.
Szuhaj Bernard F.
Coe Susan D.
Cordek James L.
Levitt Cary A.
SOLAE, LLC
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