Method of making biocompatible, surface modified materials

Details Method of making biocompatible, surface modified materials Method of making biocompatible, surface modified materials

1989-04-24

1992-01-14

Beck, Shrive

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

427 40, 427 41, 427 451, 427164, 427333, 4274123, 4274124, 4274125, 523105, 623 6, A61F 214

Patent

active

050809245

ABSTRACT:
A method of permanently modifying the surface of a substrate material so as to develop a microscopically smooth, biocompatible surface thereon comprises covalently grafting at least a first biocompatible material, preferably having pendant terminal carboxylic acid or amine groups, to the surface of the substrate material by radio frequency plasma-induced grafting. In addition, a method of permanently modifying the surface of the substrate material comprises cross-linking a second biocompatible material to the first biocompatible material grafted to the substrate material using a cross-linking agent. Further, a prosthesis used in mammals, including an intraocular lens, comprises a polymer core and at least a first biocompatible material, preferably having pendant terminal carboxylic acid or amine groups, covalently grafted to the polymer core by radio frequency plasma induction. The prosthesis used in mammals may further comprise a second biocompatible material cross-linked to the grafted first biocompatible material by a cross-linking agent.

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