Method of making and using theaflavin, theaflavin-3-gallate,...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

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07427622

ABSTRACT:
The present invention discloses methods of making a mixture of theaflavin, theaflavin-3-gallate, theaflavin-3′-gallate and theaflavin 3,3′-digallate, pharmaceutical compositions of the above mixture of theaflavins, diet supplement compositions of the above mixture of theaflavins and methods for using the above mixtures of theaflavin and pharmaceutical compositions thereof to treat or prevent various diseases. The present invention also discloses methods of making theaflavin, theaflavin-3-gallate, theaflavin-3′-gallate and theaflavin 3,3′-digallate, each as a separate compound, pharmaceutical compositions of the above compounds, diet supplement compositions of the above compounds and methods for using the above compounds to treat or prevent various diseases.

REFERENCES:
patent: 3228789 (1966-01-01), Glassman
patent: 3845770 (1974-11-01), Theeuwes et al.
patent: 3916899 (1975-11-01), Theeuwes et al.
patent: 4708834 (1987-11-01), Cohen et al.
patent: 4840966 (1989-06-01), Hara et al.
patent: 4935243 (1990-06-01), Borkan et al.
patent: 5318986 (1994-06-01), Hara et al.
patent: 5698155 (1997-12-01), Grosswald et al.
patent: 5879730 (1999-03-01), Bouwens et al.
patent: 6602527 (2003-08-01), Slaga et al.
patent: 7157493 (2007-01-01), Zhao et al.
patent: 2004/0097432 (2004-05-01), Roh-Schmidt et al.
patent: 19627344 (1999-03-01), None
patent: WO 01/93886 (2001-12-01), None
Abe et al., “Black Tea Theaflavins Are Potent Inhibitors of Squalene Epoxidase, A Key Enzyme in Cholesterol Biosynthesis,” Japanese Journal of Food Chemistry, vol. 7(1), p. 47-50 (2000).
Vinson et al., “Effect of green and black tea supplementation on lipids, lipid oxidation and fibrinogen in the hamster: mechanisms for the epidemiological benefits of tea drinking,” FEBS Letters 443:44-46 (1998).
Ishikawa et al., “Effect of tea flavonoid supplementation on the susceptibility of low-density lipoprotein to oxidative modification,” Am. J. Clin. Nutr. 66:261-266 (1997).
Finger, “In-vitro studies on the effect of polyphenol oxidase and peroxidase on the formation of polyphenolic black tea constituents”, J. Sci Food Agric, vol. 66, No. 3, 1994, pp. 293-305, XP002312128.
Patent Abstracts of Japan, 11032725, Mitsui Norin KK, Feb. 9, 1999.
Patent Abstracts of Japan, 06256180, Taiyo Kagaku Co Ltd, Sep. 13, 1994.
Chemical Abstracts, “Preparation of tea pigments for pharmaceuticals,” vol. 120, No. 63, 1994, abstract No. 144138v, p. 691 col. 1, XP002312132.
Chemical Abstracts, vol. 127, No. 26, 1997, abstract No. 355154e, Meng. ME1: “Influence of theaflavin on blood lipid and hemorheologic parameters”, p. 25 col. 2, XP002312133.
Chemical Abstracts, vol. 127, No. 14, 1997, abstract No. 19OO4Oz, Ishikawa, T. “Effect of tea flavonoid supplementation on the susceptibility of low-density lipoprotein to oxidative modification”, p. 577, XP002312134.
Chung et al., “Mechanisms of inhibition of the Ras-MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (−)-epigallocatechin-3-gallate and theaflavin-3,3′-digallate,” FASEB Journal, vol. 15, No. 11, Sep. 2001 pp. 2022-2024, XP002312129.
Hashimoto et al., “Evaluation of tea polyphenols as anti-HIV agents”, Bioorganic and Medicinal Chemistry Letters, vol. 6, No. 6, 1996, pp. 695-700, XP004135008.
Yoshida et al., “Inhibitory effect of tea flavonoids on the ability of cells to oxidize low density lipoprotein”, Biochemical Pharmacology, vol. 58, No. 11, 1999, pp. 1695-1703, XP002312131.
Alderman, “A Review of Cellulose Ethers in Hydrophilic Matrices for Oral Controlled-Release Dosage Forms,” Int. J. Pharm. Tech. Prod. Mfr. 5(3):1-9, 1984.
Bamba et al., “Release mechanisms in gelforming sustained release preparations,” Int. J. Pharm. 2:307, 1979.
Berge et al., “Pharmaceutical Salts,” J. Pharm. Sci. 66:1-19, 1977.
Leung et al., “Theaflavins in Black Tea and Catechins in Green Tea Are Equally Effective Antioxidants,” J. Nutr. 131(9):2248-2251, 2001.
Sarkar et al., “Black Tea is a Powerful Chemopreventor of Reactive Oxygen and Nitrogen Species: Comparison with Its Individual Catechin Constituents and Green Tea,” Biochem. Biophys. Res. Commun. 284(1):173-178, 2001.
Verma et al., “Osmotically Controlled Oral Drug Delivery,” Drug Dev. Ind. Pharm. 26:695-708, 2000.
Yoshino et al., “Antioxidative Effects of Black Tea Theaflavins and Thearubigin on Lipid Peroxidation of Rat Liver Homogenates Induced by tert-Butyl Hydroperoxide,” Biol. Pharm. Bull. 17(1):146-149, 1994.
“Black and Green Tea: How do they differ?”, Tea Health Facts, pp. 1-4, Sep. 3, 2002, http://www.teahealth.co.uk/th/facts/1.htm.
“Camellia sinensis(Tea)”, Biodiversity explorer, pp. 1-6, Sep. 5, 2002, http://www.museums.org.za/bio/plants/theaceae/camellia—sinesis.htm.
“Tea Polyphenols, water soluble, lipid soluble”, Wuzhou International Co., Ltd., one-page, Sep. 5, 2002, http://www.chinax.com/pages/wuzhou/tea%20polyphenols.htm.
“Herbs—Green Tea (Camellia sinensis)”, Golden Temple Ingredients-Herbs-Green Tea (Camellia sinensis), pp. 1-3, Sep. 5, 2002, http://www.goldentemple.com/Clients/KIIT/GT/Ingredients.nsf/Ingredients/Green+Tea+(Camellia . . . .
Eadington, “Tea Polyphenols and Cancer Prevention”, Eadington/SJBR/2000, pp. 1-5, Sep. 5, 2002, http://wwwchem.csustan.edu/chem4400/SJBR/00eading.htm.
Goodsall et al., “The mechanism of theaflavin oxidation during black tea manufacture”, 2ndInternational Electronic Conference on Synthetic Organic Chemistry (ECSOC-2), http://www/mdpi.org/ecsoc/, Sep. 1-30, 1998, pp. 1-3, http://ecsoc2.hcc.ru/DP—TOP2/dp119/dp119.htm.
Yang et al., “The Chemistry of Tea”, p. 1-2, Sep. 5, 2002, http://www.teatalk.com/science/chemistry.htm.
Bhagwat et al., “Flavonoid composition of tea: Comparison of black and green teas,” 1 page, USDA, Agricultural researh Services.
Diepeveen et al., “Effects of atorvastatin and vitamin E on lipoproteins and oxidative stress in dialysis patients: a randomised-controlled trial,” J. Internal Medicine 257:438-445 (2005).
Yang et al., “Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols,” Carcinogenesis 19(4):611-616 (1998).
Dong et al., “Inhibition of Tumor Promoter-induced Activator Protein I Activation and Cell Transformation by Tea Polyphenols, (−)-Epigallocatechin Gallate, and theaflavins,” Cancer Research 57:4414-4419 (1997).
Nomura et al., “Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-κB activation by tea polyphenols, (−)-epigallocatechin gallate and theaflavins,” Carcinogenesis 21(10):1885-1890 (2000).

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