Method of making a sensor with improved drift stability

Details Method of making a sensor with improved drift stability Method of making a sensor with improved drift stability

1997-02-18

1999-03-16

Krass, Frederick

Chemistry: analytical and immunological testing

Blood gas

436 11, 264 78, 264 124, 264236, 264347, 008541, 008543, 008599, 008618, 385 12, 524424, A61B 500, G01N 2177

Patent

active

058829369

ABSTRACT:
The present invention provides an optical fluorescence based sensor for measuring the concentration of a gas (e.g., CO.sub.2 or ammonia) in a medium such as blood which has improved drift stability. In a preferred embodiment, the sensors of the present invention comprise microcompartments of an aqueous phase having a pH sensitive sensing component within a hydrophobic barrier phase. The sensors of the present invention are substantially free of partitioning species other than the analyte of interest which can migrate from one phase to the other in response to a change in pH in the aqueous phase and which substantially affect the concentration dependent signal. In an alternative embodiment, the sensors of the present invention are constructed so as to retard the migration of partitioning species, thus reducing the initial rate of drift.

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