Method of making a reversible matrix drug delivery system

Details Method of making a reversible matrix drug delivery system Method of making a reversible matrix drug delivery system

2006-06-20

2006-06-20

Hartley, Michael (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C424S484000, C424S485000

Reexamination Certificate

active

07063863

ABSTRACT:
A method for producing a drug system which is a reversible gelled matrix with entrapped drug. The gel is made by combining a polysaccharide, such as dextran, a polymer of glucose, with a natural macromolecule, such as the lectin, concanavalin A, with binding sites for monomers of the polysaccharide. The drug is released in response to exposure of the matrix to free carbohydrate containing the monomer of the polysaccharide for which the natural macromolecule binds.

REFERENCES:
patent: 5830506 (1998-11-01), Taylor
patent: 5902607 (1999-05-01), Taylor
patent: 6410053 (2002-06-01), Taylor
Brownlee et al., Medline Abstr., #84029525, 1984.

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