Method of making a perorally administered solid drug with contro

Details Method of making a perorally administered solid drug with contro Method of making a perorally administered solid drug with contro

1998-04-24

2000-09-12

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424457, 424458, 424459, 424468, 424469, 424470, 424474, 424475, A61K 922, A61K 926, A61K 928, A61K 948, A61K 952

Patent

active

061174505

ABSTRACT:
The method of making a solid drug with controlled effective ingredient delivery for oral administration includes selecting a predetermined number of at least three of four compressed compositions containing an effective ingredient or effective ingredient combination defined by their release profile of effective ingredient and/or effective ingredient combination. The solid drug or medicinal preparation is formed according to known methods requiring only comparatively small apparatus expense and minimal time. Perorally administered solid drugs are made by this process which can provide widely varying pharmaceutically-required release profiles of effective ingredients or effective ingredient combinations, for example delayed release, uniformly maintained release or pulsatile release adjusted to fit a special rhythm.

REFERENCES:
patent: 5229131 (1993-07-01), Amidon et al.
Mutschler, E., et al: "Arzneimittelwirkungen", Lehrbuch der Pharmakologie and Toxikologie, 7. Aufl. Wissemschdftliche Verlagsgesekkschaft mbH Stuttgart 1996, s. 12.
Bauer, K. H., et al: Pharmazeutische Technologie, 4. Auflage, Georg Thieme Verlag Stuttgart, New York, 1993, s. 357-358.
Nuernberg, E. und Surmann, P.: hagers handbuch, bD. 2-Metoden, 5. vollst.neubearb. Auf., Springer Verlag Berlin, Heidelberg, New York, 1991, s. 1122-1123.
Ouriemchi, E. M., et al: "Oral dosages Forms with a Core and Shell with the Same Polymer Containing Different Drug Concentrations", Int. J. Pharm 102, s. 47-54 4-93.
Diluccio, R.C., et al: "Susteined-Release Oral Delivery of Theophylline by Use of Polyvinyl Alcohol and Polyvinyl . . . ", J. Phar. Scien., 83 (1994), pp. 104-106.
Meshali, M., M., et al: "Preparation and Evalution of Theophylline Sustained-Release Tablets", Drug Develop. Ind. Pharm, 22 (1996), pp. 373-376.
Junginger, H. E.: "Oral Applications of Pulsatile Drug Delivery", Pulsatile Drug Delivery, Ed. 1. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, 1993, pp. 113-134.
Bauer, K. H., et al: "Coted Pharmaceutical Dosage Forms", CRC Press, New York, Washington, D.C., medpharm Scientific Publishers, Stuttgart, 1998, pp. 222-225, 230,231.
U.S.P. 23<724>, 1996-1997, USPC, Inc.

Affiliated with

Also associated with

Rating

Method of making a perorally administered solid drug with contro does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of making a perorally administered solid drug with contro, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of making a perorally administered solid drug with contro will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-93282