Method of making a fominoben/theophylline complex

Details Method of making a fominoben/theophylline complex Method of making a fominoben/theophylline complex

1979-08-08

1981-01-20

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D41302

Patent

active

042464072

ABSTRACT:
Fominoben/theophylline complex is disclosed having the formula: ##STR1## In pharmaceutical oral preparations (dragees or syrup) the complex is usable in dosages corresponding to those of Fominoben hydrochloride, without exhibiting, however, a bitter nauseating taste.
The complex is prepared by refluxing a solution of Fominoben hydrochloride and theophylline sodium salt in equimolar proportions in an alcoholic solvent while at the same time dehydrating the reflux stream.

REFERENCES:
Farbenind, Chem. Abstracts, vol. 37 (1937) p. 418.sup.7.

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