Method of making 2'-O-alkyl pyrimidine ribonucleosides

Details Method of making 2'-O-alkyl pyrimidine ribonucleosides Method of making 2'-O-alkyl pyrimidine ribonucleosides

1994-12-13

1998-05-26

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 536 268, 536 2851, C07H 1910

Patent

active

057567077

ABSTRACT:
Method for production of 2'-O-derivatized uridine and cytosine RNA synthons comprising derivatizing the 2'-hydroxyl group of a partially protected cytosine ribonucleoside to preferentially produce a partially protected 2'-O-derivatized nucleoside, which is then either (1) reacted at the 3'-hydroxyl group to produce a 2'-O-derivatized cytosine RNA synthon, or (2) reacted with a hydroxide source to produce a uridine nucleobase by deamination, thereby producing a partially protected 2'-O-derivatized uridine ribonucleoside which can be reacted at its 3'-hydroxyl group to produce a uridine RNA synthon.

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