Method of making 2,7-dimethyl-2,4,6-octatrienedial and derivativ

Details Method of making 2,7-dimethyl-2,4,6-octatrienedial and derivativ Method of making 2,7-dimethyl-2,4,6-octatrienedial and derivativ

1991-03-04

1992-04-21

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

560195, 568449, 568484, C07C 4721, C07C 4500

Patent

active

051070308

ABSTRACT:
The present invention is an improved method to prepare 2,7-dimethyl-2,4,6-octatrienedial and related derivative compounds. This method of making 2,7-dimethyl-2,4,6-octatrienedial and derivatives thereof includes reacting 2-butenyl-bisphosphonic acid tetraalkyl ester and at least two equivalents of protected pyruvic aldehyde derivative in a nonpolar organic solvent in the presence of an alkali metal hydroxide. Compounds prepared by this invention are useful intermediates in the preparation of carotenoids.

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O. Isler, Carotenoids, pp. 431-437.
Horst Pommer et al., Industrial Applications of the Wittig Reaction, vol. 109 (1983) pp. 165-188.
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Carsky et al., Liebigs Ann. Chem. (1980) 291-304.
The Chemist's Companion, Drying Agents, pp. 445-447.
Shyam K. Gupta, J. Org. Chem., vol. 41, No. 15 (1976).

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