Method of making 2,4,5-trihalobenzoic acid

Details Method of making 2,4,5-trihalobenzoic acid Method of making 2,4,5-trihalobenzoic acid

1992-05-11

1993-03-23

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 6304

Patent

active

051965909

ABSTRACT:
Disclosed is a method of making 2,4,5-trihalobenzoic acid by heating to a temperature of about 130.degree. to about 190.degree. C. a composition that comprises water, a mineral acid, and a compound having the general formula ##STR1## where "X" is fluorine, chlorine, or bromine and "R" is alkyl from C.sub.1 to C.sub.10 or aryl. The fluorine product is useful in making quinolone antibacterial drugs.

REFERENCES:
patent: 2439237 (1968-04-01), Cass et al.
patent: 4769492 (1988-09-01), Kaieda et al.
patent: 4769493 (1988-09-01), Ito et al.
patent: 4935541 (1090-06-01), O'Reilly

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