Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-04-05
1987-03-24
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514397, 514478, A61K 3144, A61K 31415, A61K 3127
Patent
active
046525718
ABSTRACT:
A method of maintaining ruminants on a relatively high energy, low fiber diet comprising the step of administering a controlled dosage of a parasympathomimetic compound, particularly slaframine, to the ruminants at or about the time of feeding, whereby saliva flow and rumen digesta turnover rates are beneficially increased and the risks of certain digestive tract disorders are decreased.
REFERENCES:
Goodman and Gilman's The Pharmacological Basis of Therapeutics, 6th Ed., 91.
Booth and McDonald, Veterinary Pharmacology and Therapeutics, 5th Ed., 137, Table 6.1, 74.
F. Peter Guengerich and Steven D. Aust, "Activation of the Parasympathomimetic Alkaloid Slaframine by Microsomal and Photochemical Oxidation" Molecular Pharmacology 13, 185-195.
Veterinary Pharmacology and Therapeutics, (4th Edition), Chapter 8, pp. 136-164.
"Slaframine, a Toxin Causing Salivation, Lacrimation, Urination, and Defecation", p. 1287 in Veterinary Pharmacology and Therapeutics, edited by Jones, Booth and McDonald, (Fourth Edition, The Iowa State University Press, 1978).
"Parasympathomimetic, Parasympatholytic, and Autonomic Ganglionic Blocking Agents" (extracts), by Adams, pp. 136-148, 163-164 in Veterinary Pharmacology and Therapeutics, edited by Jones, Booth and McDonald (Fourth Edition, The Iowa State University Press, 1978).
"Rhizoctonia leguminicola--Salframine" by S. C. Aust, pp. 98-109 in Mycotoxins, edited by I. F. H. Purchase (Elsevier Publication Company, 1974).
"Effect of Slaframine on Exocrine Gland Function" by S. D. Aust, pp. 427-433 in vol. 19 Biochemical Pharmacology (Pergamon Press, 1970).
"Drugs Affecting Digestion and Absorption" (extracts), by Phillips and Lewis, pp. 711, 723-725 in Veterinary Pharmacology and Therapeutics, edited by Jones, Booth and McDonald (Fourth Edition, The Iowa State University Press, 1978).
"New Drug Stimulates Exocrine Glands; Might Help Cystic Fibrosis Patients" in News and Comment from The Institute of Biology and Medicine, Michigan State University, vol. 4, No. 4 (Apr. 1968).
"Chemistry and Physiology of Slaframine" pp. 449-457 in Mycotoxic Fungi, Mycotoxins, Mycotoxicoses, edited by Wyllie and Morehouse (Marcel Dekker, Inc., N.Y., 1977).
"Lysine Metabolism and Slaframine Biogenesis" by F. P. Guengerich, 30 Fed. Proc. 1067 (1971) (Abstract 84).
"Salivary Syndrome in Horses: Identification of Slaframine in Red Clover Hay" by Hagler and Behlow, pp. 1067-1073 in vol. 42 of Applied and Environmental Microbiology (Dec. 1981).
"A Method for Investigating Salivation in Cattle Using Pilocarpine as a Sialagogue" by Gurnsey, Jones and Reid, pp. 33-41 in N.Z. Journal of Agricultural Research, vol. 23 (1980).
"Low-Fat Milk, Displaced Abomasum and Their Relationship to the Feeding of High-Grain, Low-Fiber Diets to Lactating Dairy Cows" by Croom, pp. 59-62, in 1980 Report, Department of Animal Science, North Carolina State University.
"Physiological Changes in Ruminants Being Fed High Energy Feeds" by Dougherty, pp. 49-60 in Buffers in Ruminant Physiology and Metabolism, edited by Weinberg and Sheffner (Church & Dwight Company, Inc., 1975).
"Bovine Saliva: Production and Function" by E. E. Bartley, pp. 61-77 in Buffers in Ruminant Physiology and Metabolism, edited by Weinberg and Sheffner (Church & Dwight Company, Inc., 1976).
"The Use of Buffers in the Rations of Lactating Dairy Cows" by C. L. Davis, pp. 51-64 in Regulation of Acid-Base Balance, (Church & Dwight Company, Inc., 1979).
"Manipulation of Rumen Fermentation in Sheep by Increasing the Rate of Flow of Water from the Rumen" by Harrison, Thomson and Osbourn, 85 J. Agric. Society 93-101 (1975).
"Effects of Administration of Glucocorticoids on Pancreas and Growth of Dairy Calves" by Pelletier and Dunnigan, 66 J. Dairy Science, 1329-1336 (1983).
Croom, Jr. Warren J.
Hagler, Jr. Winston M.
North Carolina State University
Waddell Frederick E.
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