Method of magnetic resonance imaging of the liver and spleen

Details Method of magnetic resonance imaging of the liver and spleen Method of magnetic resonance imaging of the liver and spleen

1985-05-08

1987-06-23

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

128653, 128654, 436173, 436526, 436806, 252 6251, A61K 4900, A61B 505, A61B 600

Patent

active

046751734

ABSTRACT:
A method of magnetic resonance imaging (MRI) of liver and/or spleen is provided employing encapsulated contrast agents in the form of microspheres having a biodegradeable matrix with the paramagnetic/ferromagnetic contrast agent dispersed therein. Ferromagnetic contrast agents such as magnetite are preferred. Ferromagnetic microspheres when administered intravenously segregate through the reticuloendothelial system in the liver and spleen where they reduce the T.sub.2 relaxation time to obtain improved MR imaging.

REFERENCES:
patent: 4247406 (1981-01-01), Widder et al.
patent: 4452773 (1984-06-01), Molday
patent: 4615879 (1986-10-01), Runge et al.
Wesby et al., Radiology (1983) 149:175-180.
Runge et al., Radiology (1983) 147:789-791.
Stark et al., Radiology (1983) 148:743-751.
Becker, "High Resolution NMR", (2nd ed., 1980, Academic Press), pp. 48-51.

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