Method of lyophilizing cold insoluble globulin

Details Method of lyophilizing cold insoluble globulin Method of lyophilizing cold insoluble globulin

1983-10-03

1986-01-21

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260121, 424101, 514 8, 514 21, C07G 700, A61K 3514

Patent

active

045656517

ABSTRACT:
A lyophylized cold insoluble globulin preparation can be prepared in stable condition and in short time by lyophylizing an aqueous solution of a cold insoluble globulin in the presence of albumin and a neutral amino acid, a monosaccharide, a disaccharide or a sugar alcohol. The preparation dissolves in water without occurrence of turbidity and is usable for injection.

REFERENCES:
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patent: 4278594 (1981-07-01), Amrani
patent: 4305871 (1981-12-01), Shanbrom
patent: 4315906 (1982-02-01), Gelder
patent: 4327086 (1982-04-01), Fukushima et al.
patent: 4341764 (1982-07-01), Wallace et al.
patent: 4424206 (1984-01-01), Ohmura et al.
patent: 4440679 (1984-04-01), Fernandes et al.
Kirk et al., Encyclopedia of Chemical Technology, vol. 3, 1964, 2d Edition, pp. 572-573.

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