Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1980-09-10
1982-02-23
Cacciapaglia, Jr., Frank
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424247, 424258, 424262, 424274, 424324, A61K 3133, A61K 3147, A61K 3154, A61K 31475
Patent
active
043168973
ABSTRACT:
Benzodiazepine derivatives which have tranquillizing activity, especially 1,4-benzodiazepine derivatives, can lower the serum prolactin concentration. They can reduce, dosage-dependently, the increase in the serum prolactin concentration induced by the administration of neuroleptics, which can lead to undesirable side-effects, when about 0.01 to 100 parts by weight of benzodiazepine derivatives are administered per part by weight of neuroleptic, it being immaterial whether the benzodiazepine derivative is administered before or after the neuroleptic or simultaneously therewith. The simultaneous administration of the active substances can be carried out as an ad hoc combination or in the form of a pharmaceutical combination.
REFERENCES:
patent: 3864486 (1975-02-01), Blum
Merck Index, 9th Ed. (1976) Entry 6391.
Merck Index, 9th Ed. (1976) Entry 8786.
Cacciapaglia, Jr. Frank
Hoffman Frank P.
Hoffmann-La Roche Inc.
Leon Bernard S.
Saxe Jon S.
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