Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Dissolving or eluting from solid or gel matrix
Patent
1997-11-03
1999-08-24
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Dissolving or eluting from solid or gel matrix
424 129, 424 121, 424 137, 424 133, 600 1, 600 3, 600 4, 600 7, 600 8, A61K 5108, A61N 500
Patent
active
059422092
ABSTRACT:
Locally deposited polymer depots are used as a vehicle for the immobilization and local delivery of a radionuclide or radiopharmaceutical. Radionuclides are incorporated in their elemental forms, as inorganic compounds, or are attached to a larger molecule or incorporated into the polymer, by physical or chemical methods. Ancillary structure may be employed to control the rate of release. Standard radionuclides which have been used for local radiotherapy may be used, such as radionuclides of iodine, iridium, radium, cesium, yttrium or other elements.
REFERENCES:
patent: 4115540 (1978-09-01), Digenis et al.
patent: 5084002 (1992-01-01), Liprie
patent: 5102666 (1992-04-01), Acharyg
patent: 5256765 (1993-10-01), Leong
patent: 5410016 (1995-04-01), Hubbell et al.
patent: 5493007 (1996-02-01), Burnier et al.
patent: 5498227 (1996-03-01), Mawad
patent: 5503614 (1996-04-01), Liprie
patent: 5514379 (1996-05-01), Weissleder et al.
patent: 5527864 (1996-06-01), Suggs et al.
patent: 5575749 (1996-11-01), Liprie
patent: 5575815 (1996-11-01), Slepian et al.
patent: 5594136 (1997-01-01), Sessler et al.
patent: 5611767 (1997-03-01), Williams
patent: 5616114 (1997-04-01), Thornton et al.
patent: 5618266 (1997-04-01), Liprie
patent: 5643171 (1997-07-01), Bradshaw et al.
Ball, et al., "Silicone implant to prevent visceral damage during adjuvant Radiotherapy for retroperitoneal sarcoma," Brit. J. radiology 63(749):346-348 (1990).
Bottcher, et al., "Endovascular irradiation--A new method to avoid recurrent stenosis after stent implantation in peripheral arteries: Technique and preliminary results," Int. J. Radiation Oncology Biol. Phys. 29(1):183-186 (1994).
Chemical Abstract 109:125450 Furukawa et al., Jpn. Kokai Tokkyo Koho, JP 62254773 A2, Abstract, 1988.
Chemical Abstracts No. 125(9):109075, Ning et al., "Intratumoral radioimmunotherapy of a human colon cancer xenograft using a sustained-release gel," Radiother. Oncol. 39(2):1790189 (1996).
Durrani, et al., "Precorneal Clearance of Mucoadhesive Microspheres from the Rabbit Eye," J. Pharm. Pharmacol. 47(7):581-584 (1995).
Friedman, et al., "The Antiatherogenic Effect of Iridium.sup.192 upon the Cholesterol-fed Rabbit," J. Clin. Invest., 43(2):185-192 (1964).
Friedman, et al., "Aortic Atherosclerosis Intensification in Rabbits by Prior Endothelial Denudation," Arch. Path. 79:345-356 (1965).
Friedman, et al., "Effect of Iridium 192 Radiation on Thromboatherosclerotic Plaque in the Rabbit Aorta," Arch. Path. 80:285-290 (1965).
Furukawa, et al., "Catheter for in situ cavity irradiation for radio therapy," CA vol. 109(15) Abstract No. 125450 (1988).
Laakso, et al., "Biodegradable Microspheres X: Some Properties of Polyacryl Starch Micorparticles Prepared From Acrylic Acid Esterified Starch," J. Pharm. Sci., 76(12):935-939 (1987).
Medical Industry Today, Abstract No. 08219606, "Novoste, Emory Univ. Settle Patent Flap," (Aug. 21, 1996).
Medical Industry Today, Abstract No. 10259606, "IsoStent Completes First Human Implants of Stents," (Oct. 25, 1996).
Medical Industry Today, Abstract No. 11059608, "Novoste Trial Enrollment Complete, Poised to Begin Trials," (Nov. 5, 1996).
Medical Industry Today, Abstract No. 02209704 "Radiosotope Stent In Test to Treat Cardiovascular Disease," (Feb. 20, 1997).
Medical Industry Today, Abstract No. 02259706, "Medtronic Invests In On-Demand Blood Radiation Technology," (Feb. 25, 1997).
Medical Industry Today, Abstract No. 05059709, "Oncoath Cash Infusion Advances Cancer Treatment Systems," (May 5, 1997).
Weshler, et al., "Prevention of neointimal formation in de-endothilialized rat aorta" Abstract--Proc. 21st Ann. Meeting, European Soc. Radiation Biol. (1988).
Avila Luis Z.
Leavitt Richard D.
Dees Jos,e G.
Focal, Inc.
Hartley Michael G.
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