Method of lightening skin

Drug – bio-affecting and body treating compositions – Bleach for live hair or skin

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424401, 4241951, 514283, 206287, A61K 748

Patent

active

059194367

ABSTRACT:
A method and composition for the topical application of a yohimbine or derivative or stereoisomer thereof or effective .alpha..sub.2 -antagonists, to the skin for inhibiting melanogenesis in the skin leading to skin lightening. The yohimbine may be provided as a natural extract, for example, as an extract of Johimbe bark.

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Morishita, F., Responses of the melanophores of the medaks, Oryzias latipes, to adrenergic drugs: evidence for nvolvement of alpha2 adrenergic receptors mediating melanin aggregation, 1987.

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