Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Reexamination Certificate
2005-02-15
2005-02-15
Housel, James (Department: 1648)
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
C435S005000, C435S325000, C435S364000, C424S226100
Reexamination Certificate
active
06855535
ABSTRACT:
The present invention provides methods of large scale production of Hepatitis A Virus (HAV) on VERO cells bound to microcarrier. The invention also provides for methods of isolation of HAV from the cell culture supernatant of HAV infected VERO cells.
REFERENCES:
patent: 4783407 (1988-11-01), Provost et al.
patent: 4894228 (1990-01-01), Purcell et al.
patent: 5607851 (1997-03-01), Pellegrini et al.
patent: 5980901 (1999-11-01), Shih et al.
patent: WO9524468 (1995-09-01), None
patent: WO9615231 (1996-05-01), None
André, et al. “Inactivated Candidate Vaccines for Hepatitis A”Prog. Med. Virol. (1990) vol. 37, pp. 72-95.
Armstrong, et al. “Development of the Formalin-inactivated Hepatitis A Vaccine VAQTA™ From the Live Attenuated Virus Strain CR326F”J. of Hepatology(1993) vol. 18, pp. 20-26.
Aunins, et al. “Reactor Development for the Hepatitis A Vaccine VAQTA™”Animal Cell Technology(1997) pp. 175-183.
Binn, et al. “Primary Isolation and Serial Passage of Hepatitis A Virus Strains in Primate Cell Cultures”J. of Clinical Microbiology(Jul. 1984) vol. 20(1), pp. 28-33.
Bishop, et al. “Rapid and Efficient Purification of Hepatitis A Virus From Cell Culture”J. of Virological Methods(1994) vol. 47, pp. 203-216.
Bishop, et al. “Hepatitis A Virus Subviral Particles: Purification, Accumulation, and Relative Infectivity of Virions, Provirions, and Procapsids”Arch Virol. (1997)—vol. 142, pp. 2147-2160.
Butler, M. A. Comparative Review of Microcarriers Available for the Growth of Anchorage-dependent Animal CellsAnimal Cell Biotechnology, Ed. R.E. Spier and J.B. Griffiths(1988) vol. 3, pp. 284-303.
Cohen, et al. “Hepatitis A Virus cDNA and Its RNA Transcripts are Infectious in Cell Culture”J. of Virology(Oct. 1987), vol. 61(10), pp. 3035-3039.
Flehmig, et al. “Immunogenicity of a Hepatitis A Virus Vaccine”J. of Medical Virology(1987) vol. 22, pp. 7-16.
Junker, et al. “Evaluation of a Microcarrier Process for Large-scale Cultivation of Attenuated Hepatitis A”Cytotechnology(1992) vol. 9, pp. 173-187.
Kistner, et al. “Development of a Mammalian Cell (Vero) Derived Candidate Influenza Virus Vaccine”Vaccine(1998) vol. 16(9/10), pp. 960-968.
Lemon, et al. “Antigenic Structure of Hepatitis A Virus”Molecular Aspects of Picornavirus and Detection Ed. B.L. Semler and E. Ehrenfeld(1989) (1989) pp. 193-208.
Locarnini, et al. “Restricted Replication of Human Hepatitis A Virus in Cell Culture: Intracellular Biochemical Studies”J. of Virology(Jan. 1981) vol. 37(1), pp. 216-225.
Nasser, et al. “Production of Cytopathology in FRhK-4 Cells by BS-C-1-Passaged Hepatitis A Virus”Applied and Environmental Microbiology(Dec. 1987) vol. 53(12), pp. 2967-2971.
Simmonds, et al. “Persistently Infected Cultures as a Source of Hepatitis A Virus”Applied and Environmental Microbiology(Apr. 1985) vol. 49(4), pp. 749-755.
Widell, et al. “A Microcarrier Cell Culture System for Large Scale Production of Hepatitis A Virus”J. of Virological Methods(1984) vol. 8, pp. 63-71.
Yokosawa, et al. “Affinity Chromotography of Trypsin and Related Enzymes”J. of Biochem. (1976) vol. 79, pp. 757-763.
Barrett Noel
Dorner Friedrich
Meyer Heidi
Mundt Wolfgang
Reiter Manfred
Baxter Healthcare S.A.
Chen Stacy B.
Housel James
LandOfFree
Method of large scale production of Hepatitis A virus does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of large scale production of Hepatitis A virus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of large scale production of Hepatitis A virus will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3505618