Method of labeling complex metal chelates with radioactive metal

Details Method of labeling complex metal chelates with radioactive metal Method of labeling complex metal chelates with radioactive metal

1974-05-22

1976-02-03

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424201, C07H 2300

Patent

active

039364402

ABSTRACT:
A method is provided for labeling a complex metal chelate with a radioactive metal isotope via isotopic exchange between the metal atom of the complex metal chelate and the radioactive metal isotope. The complex metal chelate, in a suitable redox state, is mixed in solution with a radioactive metal isotope, freeze-dried, exposed to an electron-accepting gas and thereafter subjected to thermal treatment, whereby isotopic exchange occurs and the complex metal chelate is labeled with the radioactive metal isotope. Furthermore, an additional step comprising exposure to an atmosphere of high relative humidity is provided to increase the yield of isotopic exchange.

REFERENCES:
patent: 3505019 (1970-04-01), Axen et al.

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