Method of killing tumor cells

Drug – bio-affecting and body treating compositions – Immune response affecting drug

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4242781, 424722, 514 3, 514 4, A61K 3828, A61K 3314, A61K 4505

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active

058407707

ABSTRACT:
This invention provides an immunoenhancement or immune-potentiation therapy comprising administration of potassium, insulin, glucose and, optionally, thyroid, a cholinergic agent and bicarbonate. Therapeutic compositions comprising the above components in appropriate dosages are also provided.

REFERENCES:
patent: 4061537 (1977-12-01), Seiler et al.
patent: 4196196 (1980-04-01), Tiholiz
patent: 4971951 (1990-11-01), Garcia y Bellon et al.
patent: 5033998 (1991-07-01), Corday et al.
patent: 5155096 (1992-10-01), Garcia y Bellon et al.
Aitakov et al. Correction of Water-Electrolyte Balance and Acid-Base Equilibrium in Stomach Cancer. Khirurgiia-Mosk. Apr.(4), pp. 76-80. (1974). Abstract Only.
Goos et al. Influence of Verapramil & Its Combination With Glucose-Insulin-Potassium-Infusion on Acute Myocardial Ischemia in Dogs. Biomed-Biochim-Acta. 46(8-9), S597-601. (1987). Abstract Only.
Fang et al. A Modified Formula of GIK (Glucose-Insulin-Potassium) Therapy for Treatment of Extensive Burn Injury in Dogs. J. Trauma, 29(3),pp. 344-349. Mar. 1989. Abstract Only.
Malling et al. Perioperative Treatment of Diabetics. Ugeskr-Laeger, 153(10),pp. 698-701. Mar. 1991. Abstract Only.
Girard et al. Glucose and Insulin Supply Before Cardiopulmonary Bypass in Cardiac Surgery: A Double-Blind Study. Annals Thoracic Surgery. 54(2),pp. 259-263. Aug. 1992. Abstract Only.
Old, L.J. (1988), "Tumor Necrosis Factor," Scientific American 258:59-75.
Patillo, R. (1974) "Trophoblast Cancers," in Hormones and Cancer, (K.W. McKerns, ed.), Academic Press, New York, pp. 363-387.
Prehn, R.T. (1976), "Do Tumors Grow because of the Immune Response of the Host?" Transplantation Reviews 28:34-42.
Ellenhorn, J.D. et al. (1988), "In vivo Administration of Anti-CD3 Prevents Malignant Progressor Tumor Growth," Science 242:569-571.
Golde, D.W. et al. (1988), "Hormones that Stimulate the Growth of Blood Cells," Scientific American 259:62-70.
Bevilacqua M.P. et al. (1989), "Endothelial Leukocyte Adhesion Molecule 1: an Inducible Receptor for Neutrophils Related to Complement Regulatory Proteins and Lectins," Science 243:1160.
Oppenheim, J.J. et al. (1987), in Basic and Clinical Immunology, Sixth ed., (D.P. Stites, et al., eds.), Appleton and Lange, Los Altos, CA, p. 94.
Rosenberg, S.A. et al. (1986), "A New Approach to the Adoptive Immunotherapy of Cancer with Tumor-infiltrating Lymphocytes," Science 233:1318-1321.
Geiger, J.D. et al, (1993), "Generation of T-Cells Reactive to the Poorly Immunogenic B16-BL6 Melanoma with Efficacy in the Treatment of Spontaneous Metastases," J. Immunother. 13:153-165.
Chang, A.E. et al. (1993), "Clinical Observations on Adoptive Immunotherapy with Vaccine-primed T-Lymphocytes Secondarily Sensitized to Tumor In Vitro," Cancer Res. 53:1043-1050.
Handwerger, B.S. and Douglas, S.D., (1980) "The Cell Biology of Blastogenesis," in The Cell Biology of Inflammation, (G. Weissmann, ed.), Elsevier, New York/N. Holland Biomedical Press, Amsterdam, pp. 652-657.
Lawrence, T.S. and Davis, M.A. (1990), "The Influence of Na.sup.+, K.sup.+ -pump Blockade on Doxorubicin-mediated Cytotoxicity and DNA Strand Breakage in Human Tumor Cells," Cancer Chemother. and Pharmacol. 26:163-167.
Owens, T. and Kaplan, J.G. (1981), "Monovalent Cation Fluxes in Activated Mouse T- and B-Lymphocytes,"in Mechanisms of Lymphocyte Activation(Resch, K. and Kirchner, H. eds.) pp. 238-241.
Grinstein, S. and Dixon, S.J. (1989), "Ion Transport, Membrane Potential, and Cytoplasmic pH in Lymphocytes: Changes during Activation," Physiol. Rev. 69:417-481.
Cahalan, M.D. et al. (1991), "Potassium Channels in Development, Activation, and Disease in T Lymphocytes," in Developmental Biology of Membrane Transport Systems(Benos, D.J., ed.), pp. 357-394.
Gerson, M., A Cancer Therapy: Results of Fifty Cases, (New York: Dura Books, Inc., 1958), pp. 237-248.
Edgington, S.M. (1993), "Looking Death in the Eye: Apoptosis and Cancer Research--Is Cancer really Caused by Cells Refusing to Commit Suicide on Cue?," Bio/Tech. 11:787-792.
Hardin, J. A., et al. (1992), "A Simple Fluorescence Method for Surface Antigen Phenotyping of Lymphocytes Undergoing DNA Fragmentation," J. Immuno. Meth. 154:99-107.
Ojcius, D.M., et al. (1991), "Ionophore-Induced Apoptosis: Role of DNA Fragmentation and Calcium Fluxes," Exp. Cell Res. 197:43-49.
McGrady, P. (1964), The Savage Cell, Basic Books, Inc., New York, pp. 138-140.
Kassirer, Jerome P., et al. (1989), Repairing Body Fluids: Principles and Practice, p. 46-72.
Koffler, Michael, et al. (1991), "Immunobiological Consequence of Regulation of Insulin Receptor on Alloactivated Lymphocytes in Normal and Obese Subjects," Diabetes40:364-370.
Coffey, Ronald G. and Hadden, John W. (1984), "Cyclic Nucleotides in Neurohumoral and Hormonal Regulation of Cells of the Immune System," in Stress, Immunity and Aging(Cooper, E.L., ed.) p. 231 ff.
Strom, Terry B., et al. (1975), "Insulin-Induced Augmentation of Lymphocyte-Mediated Cytotoxicity," Science187:1206-1208.
Ercolani, L., et al. (1985), "Insulin-Induced Desensitization at the Receptor and Postreceptor Level in Mitogen-Activated Human T-lymphocytes," Diabetes:34:931-937.
Morrison, S.D. (1982), "Feeding Response of Tumor-bearing Rats to Insulin and Insulin Withdrawal and the Contribution of Autonomous Tumor Drain to Cachectic Depletion," Cancer Res.42:3642-3647.
Moley, J.F., et al. (1985), "Insulin Reversal of Cancer Cachexia in Rats," Cancer Res.45:4925-4931.
Moley, J. F., et al. (1983), "Effects of Exogenous Insulin Administration on Food Intake, Body Weight Change, and Tumor Doubling Time," Surgical Forum35:91-93.
Schein, Philip S., et al. (1979), "Cachexia of Malignancy," Cancer43:2070-2076.
Strom, T.B., et al. (1977), "The Role of Cyclic Nucleotides in Lymphocyte Activation and Function,"in Progress In Clinical Immunology(Schwartz, R.S., ed.) at 115-153.
Ignarro, L.J. and Cech, S.Y. (1976), "Bidirectional Regulation of Lysosomal Enzyme Secretion and Phagocytosis in Human Neutrophils by Guanosine 3',5'-Monophosphate and Adenosine 3',5'-Monophosphate (39232)," Proc. Nat. Acad. Sci.151:448-452.
Unanue, E.R. and Schreiner, G.F. (1975), "The Modulation of Immunoglobulin in B Lymphocytes and its Relevance to Immune Stimulation," Immune Recognition(Rosenthal, A.S., ed.) at 261-280.
Kasner, S.E. and Ganz, M.B. (1992), "Regulation of intracellular potassium in mesangeal cell: a fluorescence analysis using the dye, PBFI," Amer. J. Physiol.3:462-467.
Provinciali, M., et al. (1992), "Optimization of Cytotoxic Assay by Target Cell Retention of the Fluorescent Dye Carboxyfluorescein Diacetate (CFDA) and Comparsion with Conventional .sup.51 Cr Release Assay," J. Immunol. Meth.155:19-24.
Vollenweider, I. and Groseurth, P.J. (1992), "Comparsion of the Four DNA Staining Fluorescence Dyes for Measuring Cell Proliferation of Lymphokine-activated Killer (LAK) Cells," J. Immunol. Meth.149:133-135.
Loeffler, D.A., et al (1992), "Analysis of Distribution of Tumor- and Preneoplasia-Infiltrating Lymphocytes Using Simultaneous Hoechst 33342 Labeling and Immunophenotyping," Cytom.13:169-174.
Rivoltini, L., et al (1992), "Phenotypic and Functional Analysis of Lymphocytes Infiltrating Paediatric Tumours, with a Characterization of the Tumour Phenotype," Can. Immunol. Immunother.34:241-251.
Harold, F.M. (1986), The Vital Force; A Study of Bioenergetics, W.H. Freeman and Co., New York, pp. 325-326.
Segel, G.B. and Lichtman, M.A. (1976), "Potassium Transport in Human Blood Lymphocytes Treated with Phytohemagglutinin," J. Clin. Investigation 58:1358-1359; 1365-1366.
Quastel, M.R. and Kaplan, J.G. (1970) "Early Stimulation of Potassium Uptake in Lymphocytes Treated with PHA," Expl. Cell. Res.63:230-233.
Ignarro, L.J. (1975), "Regulation of Lysosomal Enzyme Release by Prostaglandins, Autonomic Neurohormones and Cyclic Nucleotides," in Lysosomes in Biology and Pathology (Dingle, J.T. and Dean, R.T., eds.) pp. 481-523.
Hadden, J.W. (1987), "Neuroendocrine Modulation of the Thymus-Dependent Immune System," Annals of the N.Y. Acad. of Sciences 496:39-48.
Tiedt, T.N. et al. (1979) "Voltage- and Time-Dependent Action

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