Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1989-06-05
1990-06-19
Huleatt, Jayme A.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4351721, 4352523, 435909, 435320, 935 56, 935 72, C12N 1500, C12N 120, C12R 163
Patent
active
049353640
ABSTRACT:
This invention relates to a method of isolating deletion mutants of Vibrio cholerae, wherein the deletion is predetermined by digestion with restriction endonucleases of known specificity. The deletions are inserted into the Vibrio cholerae chromosome by in vivo recombination betweem a plasmid carrying the desired deletion, with adjacent flanking sequences, and the Vibrio cholerae chromosome. The invention includes the isolation and characterization of a new Vibrio cholerae strain having a deletion in the tox gene, as defined by Acc I restriction endonuclease sites.
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Kaper James B.
Levine Myron M.
Cordell Ruffin B.
Huleatt Jayme A.
Kile Bradford E.
O'Brien Kevin M.
Swiss Serum and Vaccine Institute Berne
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