Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1997-11-13
1999-10-12
Saucier, Sandra E.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
435366, 424 937, C12N 508, A01N 6300
Patent
active
059654368
ABSTRACT:
The present invention is directed to isolated and purified human mesenchymal stem cells, to a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. mesenchymal stem cells or "MSCs"), and to the characterization of and uses for such cells. In particular, the invention relates to isolation of MSCs that are associated with hematopoietic cells, such as megakaryocyte precursors, in the bone marrow.
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Rabellino et al., "Human Megakaryocytes", J.Exp. Med. Jun. 1979, vol. 149, pp. 1273-1287.
Grant et al., "A radioimmunoassay useful fro quatitating megakaryocyre growth in vitro", In:Megakaryocyte Development and Function, ED. Levine et al., 1986 Alan R.Liss, Inc., pp. 117-121.
Hoffman et al., "Regulation of Megakaryocytopoisis", Blood, 1989, vol. 74, No. 4, pp. 1196-1212.
Tanaka et al., "Isolation of human megakaryocyes by immunomagnetic beads", British Jouranl of hematology, 1989, 73, 18-22.
Marshak Daniel R.
Thiede Mark A.
Afremova Vera
Olstein Elliot M.
Osiris Therapeutics, Inc.
Saucier Sandra E.
Semionow Raina
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