Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Reexamination Certificate
2006-03-15
2011-10-04
Ton, Thaian N (Department: 1632)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
C435S378000, C435S366000
Reexamination Certificate
active
08030072
ABSTRACT:
The present invention describes novel methods for isolating a substantially pure cell population of non-embryonic epidermal neural crest stem cells from the bulge-region of mammalian hair follicles. Also disclosed is the substantially pure cell population of follicular bulge-derived neural crest stem cells for medical research and therapeutic use.
REFERENCES:
patent: WO 03/054202 (2008-07-01), None
Muller et al. Nat. Reviews, 7: 75-84, 2006.
Ferletta. Mol. Can. Res., 5(9): 891-897, 2007.
Xu et al. J. of Cell Bio., 154(1): 217-229, 2001.
Kim et al. (Production of Immortalized Human Neural Crest Stem Cells, from Meth. Mol. Bio., 198: 55-65, 2002.
Xu et al. J. of Cell Bio., 154(1): 217-229, 2001.
Rao. J. Neurobiol., 32: 722-746, 1997.
Sieber-Blum. Stem Cell Rev., 4:256-260, 2008.
Claudinot, S., et al., “Long-term renewal of hair follicles from clonogenic multipotent stem cells,” PNAS 102:14677-14682 (2005).
Fernandes, K.J., et al., “A dermal niche for multipotent adult skin-derived precursor cells,” Nature Cell Biology 6:11:1082-1093 (2004).
Ito, M., et al., “Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis,” Nature Medicine 11:12:1351-1354 (2005).
Kruger, G.M., et al., “Neural Crest Stem Cells Persist in the Adult Gut but Undergo Changes in Self-Renewal, Neuronal Subtype Potential . . . ,” Neuron 35:657-669 (2002).
Li, L., et al., “Nestin expression in hair follicle sheath progenitor cells,” PNAS 100:17:9958-9961 (2003).
Sieber-Blum, M., et al., “Pluripotent Neural Crest Stem Cells in the Adult Fair Follicle,” Developmental Dynamics 231:258-269 (2004).
Sieber-Blum, M., et al., “The Adult Hair Follicle: Cradle for Pluripotent Neural Crest Stem Cells,” Birth Defects Research 72:163-172 (2004).
Sieber-Blum, M., et al, “Neural Crest Stem Cells in the Adult Mammalian Epidermis,” Faseby 18:4:Part I Abstract p. A25 (2004).
Toma, J.G., et al., “Isolation of multipotent adult stem cells from the dermis of mammalian skin,” Nature Cell Biology 3:778-784 (2001).
Hu, Y.F., et al.,“An Epidermal Neural Crest Stem Cell (EPI-NCSC) Molecular Signature,” Stem Cells 24:2692-2702 (2006).
Sieber-Blum, M., et al., “Characterization of Epidermal Neural Crest Stem Cell (EPI-NCSC) Grafts in the Lesioned Spinal Cord,” Mol. Cell. Neurosci. 32:67-81 (2006).
Thomas et al., Human neural crest cells display molecular and phenotypic hallmarks of stem cells, Human Molecular Genetics 17: 3411-3425, 2008.
Thomas et al., Human neural crest cells display molecular and phenotypic hallmarks of stem cells; Supplementary Table 8, Human Molecular Genetics 17: 3411-3425, 2008.
Grim Milos
Sieber-Blum Maya
Newcastle University
Quarles & Brady LLP
Ton Thaian N
Univerzita Karlova V Praze
Vinarov Sara D.
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