Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Separation or purification
Patent
1995-06-07
1997-12-02
Allen, Marianne P.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Separation or purification
530412, 530413, C07K 122
Patent
active
056937539
ABSTRACT:
The instant invention provides for monoclonal antibody 369.2B which is specific for the .beta.A4 peptide, and in particular the free C-terminus of .beta.A4 "1-42" but not "1-43", and stains diffuse and fibrillar amyloid, vascular amyloid, and neurofibrillary tangles. The instant invention further provides for antibody fragments and constructs thereof which have the same binding specificity. The instant invention also provides for methods of diagnosis, screening and therapeutics for treating unique forms of .beta.A4 peptide, using the antibodies of the instant invention.
REFERENCES:
patent: 4666829 (1987-05-01), Gunner et al.
Motter et al, Ann. Neurol. 38:643-648, 1995.
Vigo-Delfrey et al, Journal of Neurochemistry, 61:1965-1968, 1993.
Cazorla et al, BBA, 1270:149-56, 1995.
Iwatsubo et al Neuron, 13:45-53, Jul. 1994.
Seubert et al, Nature, 359:325-327, 24 Sep. 1992.
Harlow et al in "Antibodies-A Laboratory Manual", Cold Spring Harber Press Inc. 1988 pp. 511-552.
Glenner and Wong, "Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein" Biochem. Biophys. Res. Comm. 120: 885-890 (1984).
Master et al., "Amyloid plaque core protein in Alzheimer's disease and Down syndrome" PNAS (USA) 82: 4245-4249 (1985).
Miller et al., "Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease" Arch. Biochem. Biophys. 301: 41-52 (1993).
Suzuki et al., "An increased percentage of long amyloid B protein secreted by familial amyloid B protein precursor (BAPP.sub.717) mutants" Science 264: 1336-1340 (1994).
Yang et al., "Monoclonal antibody to the C-terminus of B-amyloid" Neuro. Report 5: 2117-2120 (1994).
Murphy et al., "Development of a monoclonal antibody specific for the COOH-terminal of B-amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disorders" Am. J. Pathol. 144: 1082-1088 (1994).
Graham Paul
Konig Gerhard
Allen Marianne P.
Bayer Corporation
Duffy Patricia A.
LandOfFree
Method of isolating .beta.A4 peptide species ending at carboxy-t does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of isolating .beta.A4 peptide species ending at carboxy-t, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of isolating .beta.A4 peptide species ending at carboxy-t will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-802474