Method of isolating and purifying sICAM-1

Details Method of isolating and purifying sICAM-1 Method of isolating and purifying sICAM-1

1995-05-18

1999-01-12

Feisee, Lila

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530412, 5303911, C07K 122

Patent

active

058592121

ABSTRACT:
The present invention relates to a soluble form of-intercellular adhesion molecule (sICAM-1) and purified and isolated human sICAM-1. This invention also relates to a purified and isolated DNA sequence encoding sICAM-1. The extracellular domain of sICAM-1 and insoluble ICAM-1 are substantially the same. ICAM-1 is involved in the process through which lymphocytes attach to cellular substrates during inflammation and serves as the major human rhinovirus receptor (HRR). sICAM-1 therefore has both the property of reducing immune inflammation and inhibiting infection of rhinovirus and Coxsackie A virus.

REFERENCES:
patent: 5235049 (1993-08-01), McClelland et al.

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