Method of intrapulmonary administration of a narcotic drug

Details Method of intrapulmonary administration of a narcotic drug Method of intrapulmonary administration of a narcotic drug

1997-03-07

1999-06-08

Bawa, Raj

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 46, A61K 912

Patent

active

059103019

ABSTRACT:
An aerosol formulation of an aerosol propellant and a base form of a narcotic drug selected from the group consisting of fentanyl, sufentanil and remfentanyl is provided. Such a formulation allows for the drug to be dissolved within the propellant and used within a device which does not require the use of a lubricant. Formulations are also disclosed which include lubricants, wherein the lubricant and propellant are both either polar or both non-polar. Thus, the lubricant component does not act as a solvent or cosolvent, but rather acts as a lubricant for the valve used for dispersing the formulation to a patient. Typical non-polar propellants include chlorofluorocarbons, which are typically used in connection with non-polar lubricants such as saturated vegetable oils, e.g. fractionated coconut oils. Typical polar propellants include hydrofluoroalkanes, which are typically used in connection with polar lubricants such as polyethylene glycols.

REFERENCES:
patent: 3812854 (1974-05-01), Michaels et al.
patent: 4814161 (1989-03-01), Jinks et al.
patent: 5225183 (1993-07-01), Purewal et al.
patent: 5230884 (1993-07-01), Evans et al.
patent: 5439670 (1995-08-01), Purewal et al.
patent: 5485827 (1996-01-01), Zapol et al.
patent: 5497944 (1996-03-01), Weston et al.
patent: 5589156 (1996-12-01), Henry
patent: 5653961 (1997-08-01), McNally et al.
patent: 5674471 (1997-10-01), Akehurst et al.
Weinhold, L.L. et al., (1993) Pharmacol. Biochem. Behav. 44(1):141-144.
Jaffe, A.B. et al., (1989) Psychopharmacology 99(3):289-293.
Newman, S.P. et al., (1981) Eur. J. Respir. Dis. 62:3-21.
Newman, S.P., et al., "How should a pressurized .beta.-adrenergic bronchodilator be inhaled?", Eur. J. Respir. Dis., 62:3-21, (1981).

Affiliated with

Also associated with

Rating

Method of intrapulmonary administration of a narcotic drug does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of intrapulmonary administration of a narcotic drug, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of intrapulmonary administration of a narcotic drug will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1682063